Solicitation NAICS 541715

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the following technical area: protein sequencing. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. A technical approach must provide a detailed scientific and technical justification that includes the following: Existing protein read capabilities including, but not limited to, read elements, measurement instrumentation and letter calling algorithms Clear technical plan to adapt existing read capabilities to achieve Phase 1 metrics Anticipated pre-processing steps required to adapt purified protein samples to the proposed sequencing approach Development of an integrated microsystem capable of achieving Phase 2 metrics Development of algorithms for letter calling capable of translating raw signal data into a specific amino acid sequence, along with an associated accuracy score Development of an integrated systems model to simulate accuracy, throughput, noise, and other relevant microsystem ch...

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